Leukocyte Reduction System (LRS) cones

Leukocyte Reduction System (LRS) provide a rich source of viable human leukocytes, making them valuable for various research applications, including:

1. IMMUNOLOGY STUDIES
   LRS cones yield abundant lymphocytes (T cells, B cells, NK cells) and monocytes, enabling studies on immune cell function, signaling pathways, and interactions. [1] [2]
    
2. CELL THERAPY AND REGENERATIVE MEDICINE RESEARCH
   The high viability and functional capabilities of cells from LRS cones make them suitable for developing cell-based therapies and studying cellular processes involved in tissue regeneration. [2]
    
3. INFECTIOUS DISEASE MODELING
   Primary human leukocytes from LRS cones can be used to study host-pathogen interactions, immune responses, and drug screening against various infectious agents. [2]
    
4. DRUG SCREENING AND TOXICOLOGY TESTING
   The availability of different leukocyte subsets from LRS cones allows for evaluating the efficacy and toxicity of drug candidates on relevant primary human cell types. [2]
    
5. STEM CELL RESEARCH
   LRS cones have been reported to contain a small population of endothelial progenitor cells and CD34+ stem cells, enabling research in stem cell biology and regenerative medicine.[3]

---

Citations
[1] https://www.youtube.com/watch?v=k6vPSnJvudc
[2] https://www.stemcell.com/processing-leukocyte-reduction-system-lrs-cones-for-downstream-cell-isolation.html
[3] https://medicine.uiowa.edu/pathology/research/research-support-pathology-services/degowin-blood-center-provision-blood-components-and-0